Literature review on pyrethroid common metabolites

A systematic literature review has been performed on the toxicological profiles of pyrethroid common metabolites 3-phenoxybenzoic acid (PBA), 3-(4’-hydroxyphenoxy)benzoic (PBA(OH)) and 3-phenoxybenzaldehyde (PBAld). Following definition appropriate search strings 1031 publications were screened by abstract, title keywords followed a screening full texts 82 publications. From these 20 could be identified to provide data relevant for profile(s) one or more metabolites. As publication covered in vitro vivo studies those have assessed twice – so that total number was considered 21. Overall, focused effects related reproductive toxicity, immunotoxicity, endocrine disruption, hepatotoxicity, cardiovascular neurotoxicity. risk bias (ROB) assessment, majority (n=13) low ROB, while two high ROB. Seven not allocated Tier 1 (low ROB) 3 (high thus grouped as 2 studies. The provided evidence PBA does appear produce any sperm motility. However, based studies, all which vitro, there are some indications PBA, PBAld PBA(OH) may interact with system. In addition, also data, shown cell cycle arrest, inhibition differentiation, generation reactive oxygen species, indicating potential immunotoxicity. associated apoptosis replicative DNA synthesis hepatocytes, along damage heart cells. © European Food Safety Authority, 2021